Next-Generation Diagnostics: T2 Biosystems
T2’s revolutionary new technology is based on clinically-proven magnetic resonance MR technology, and uses nanoparticles coupled with reagents to quickly detect—within minutes—the presence of specific substances in solution using a miniaturized, portable MRI instrument. Detection of the high level magnetic resonance signal from the solution enables the detection of low concentrations of target agents or substances.
Unlike most existing diagnostic detection techniques which are based on optical detection methods that require pure samples and multiple processing steps, T2’s technology is not optical and therefore does not require purification of biological samples. This significant advantage allows the T2 system to perform single-step processing and rapid turnaround times without the need for trained technicians.
Furthermore, the technology can accurately identify almost any specimen, including proteins, nucleic acids, or enzymes; bacterial, cancer or other cells; viruses; or small molecule drug compounds within almost any sample, including whole blood, plasma, serum and urine.
T2’s system is faster, more reliable, more portable and more readily accessible than any diagnostic testing system now on the market.
NanoDx: Validated Analytes
| Analyte |
Reference |
| Virus |
JACS 2003;125:10192 |
| Small molecules, peptides |
Small 2006; 2:1144 |
| DNA |
Cancer Research 2004; 64:639 |
| Peroxidases |
Nano Letters 2004;4:119 |
| Proteases |
Angew Chem 2003;42:1375 |
| Metalloproteinase |
Angew Chem 2006;45:3161 |
| Hormone |
Bioconj Chem 2007; 18:2024 |
| Ions |
PNAS 2007;103:14707 |
| Small molecules |
Angew Chem 2004;43:2395 |
| Bacterial Cells |
Nano Letters 2007;7:380 |
| DNA, mRNA |
Nature Biotech 2002;20:816 |
| Protein |
Bioconj Chem 2007; 18:2024
Nature Biotech 2002;20:816 |