T2Bacteria Panel

Actionable identification of critical infections

The T2Bacteria™ Panel, which is currently in clinical trials in the US and performance evaluations in the EU, identifies six of the most deadly and prevalent bacteria species that are often not covered by empiric therapy. T2Bacteria RUO Panel is currently available for Research Use Only (RUO) in the US. As with the FDA-cleared T2Candida Panel®, species-specific results direct from whole blood are available within hours of patient presentation.

Results direct from blood draw

Rapid detection and identification of sepsis-causing pathogens are critical for optimizing antimicrobial therapy to improve patient survival and substantially reduce healthcare costs. T2 Magnetic Resonance (T2MR) is the ONLY technology that can enable 95% of patients with bloodstream infections to receive targeted therapy within hours, when treatment has the most significant impact on patient outcomes.

Rapidly detect and identify species, no blood culture required

Proven technology

Today, implementation of the T2Candida Panel in approximately 130 hospitals globally has shortened length of stay, reduced antimicrobial consumption and identified patients missed by blood culture.

The T2Bacteria Panel, which runs on the same T2Dx® Instrument as the T2Candida Panel, is designed to be used on patients presenting in the emergency department or with symptomatic inpatients. Independent studies have proven that rapid detection and treatment can reduce patient mortality by 50% or more, while reducing hospital and ICU length of stay by 3 to 7 days.1,2-7

Timely and accurate results to support clinical action

Initial empiric antimicrobial therapy effectively treats about 60% of all septic patients.8 By focusing on those pathogens that often do not respond to initial empiric therapy, results from the FDA-cleared T2Candida Panel and the T2Bacteria Panel, once commercially available, may enable the administration of effective therapy within hours of patient presentation and long before blood-culture-based results are available.

T2Bacteria and T2Candida results, plus empiric therapy, are designed to empower healthcare teams to effectively treat up to 95% of septic patients within hours of patient presentation.

Impact of timely, effective sepsis treatment

  • Decreased mortality rates1
  • Shortened length of stay

    • 3 to 7 ICU days saved2-7
    • 1 to 7 hospital days saved2-7
  • Reduced use of antimicrobial drugs2-7
  • Reduced healthcare spending; savings of ~$25,000 per positive patient2-7,9
  • Improved healthcare quality metrics

T2Bacteria coverage

Gram Negative:

Escherichia coli

Klebsiella pneumoniae

Pseudomonas aeruginosa

Acinetobacter baumannii

Gram positive:

Staphylococcus aureus

Enterococcus faecium

The T2Bacteria Panel identifies ~90% of Gram Negative and ~70% of community-acquired infections in the Emergency Department.10,11

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1. Diekema, D. J., Beekmann, S. E., Chapin, K. C., Morel, K. A., Munson, E., & Doern, G. V. (2003). Epidemiology and outcome of nosocomial and community-onset bloodstream infection. Journal of Clinical Microbiology, 41(8), 3655-3660.
2. Stosor V et al. Enterococcus faecium bacteremia: does vancomycin resistance make a difference? Arch Intern Med. 1998 Mar 9;158(5):522-7.
3. Abramson MA et al. Nosocomial methicillin-resistant and methicillin-susceptible Staphylococcus aureus primary bacteremia: at what costs? Infect Control Hosp Epidemiol. 1999 Jun;20(6):408-11.
4. Kim BN et al. Clinical implications of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae bacteraemia. J Hosp Infect. 2002 Oct;52(2):99-106.
5. Sunenshine RH et al. Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis. 2007 Jan;13(1):97-103.
6. Micek ST et al. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother. 2005 Apr;49(4):1306-11.
7. Tumbarello M et al. Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy. Antimicrob Agents Chemother. 2010 Oct;54(10):4085-91.
8. Buehler, S. S., Madison, B., Snyder, S. R., Derzon, J. H., Cornish, N. E., Saubolle, M. A., … & Wolk, D. M. (2016). Effectiveness of practices to increase timeliness of providing targeted therapy for inpatients with bloodstream infections: a laboratory medicine best practices systematic review and meta-analysis. Clinical microbiology reviews, 29(1), 59-103.
9. Golan, Yoav, et al. Annals of internal medicine 143.12 (2005): 857-869.
10. Tsalik EL et al. Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. J Clin Microbiol. 2010 Jan;48(1):26-33.
11. Lazzaro F et al. Prevalence and drug susceptibility of pathogens causing bloodstream infections in northern Italy: a two-year study in 16 hospitals. Eur J Clin Microbiol Infect Dis. 2002 Dec;21(12):849-55.