Approximately 50–60% of sepsis episodes are initially diagnosed in the emergency department (ED)1 with millions of patients worldwide presenting in the ED related to bloodstream infections (BSI).2 If BSI patients are appropriately treated in the ED, the risk of unplanned and urgent rehospitalization significantly decreases with timely and appropriate antibiotic treatment.3
Early, appropriate antibiotics
According to ACEP DART* guidelines, it is recommended to administer appropriate antibiotics early – ideally within the first hour of recognition since delays can increase mortality rates.4 Inappropriate antibiotic therapy can lead to readmissions, which are 2 to 3 times more likely and more costly than readmits for heart failure, pneumonia, and COPD.5
Limitations of blood culture
While blood cultures are ordered as a part of the hospital’s sepsis alert bundle, results aren’t clinically actionable without the species ID or more. In a recent retrospective analysis of 13 hospitals and over 150,000 blood cultures, investigators reported that the median time to blood culture positivity and species identification was 43 hours6 – which is not fast enough to help guide physicians in early and appropriate antibiotic therapy for patients admitted into the hospital ED.6
Rapid diagnostics within hours
Rapid diagnostic test results for patients presenting in the ED can enable physicians to better manage and treat patients faster.
“You’ve Got To Be Quick, You’ve Got To Be Right”
T2Direct Diagnostics is the first and only FDA-cleared and CE-marked system to identify deadly sepsis-causing pathogens directly from whole blood without the need for blood culture. The T2Bacteria® Panel delivers faster, easier, and more accurate test results in 3 to 5 hours. The addition of T2Bacteria to a hospital’s sepsis protocol can get patients on the right treatment earlier and have a positive impact on patient care.
How rapid identification of a bacterial bloodstream infection fits into an emergency department sepsis protocol. ~ Dr. Frank Peacock, Professor of Emergency Medicine, Associate Chair, Research Director for the Department of Emergency Medicine at Baylor College of Medicine.
Accurate results without antimicrobial interference
In the T2Bacteria pivotal clinical trial conducted in 11 U.S. centers with 1,427 patients, investigators demonstrated positive and highly accurate results 2.5 days faster and without the antimicrobial interference that can affect blood culture results.6
Contact us to request a demo of the T2Bacteria Panel!
1. Garnacho-Montero J, et al. Critical Care, 2015
2. National Hospital Ambulatory Medical Care Survey: 2011 Emergency Department Summary Tables
3. Chan, J. et al. Canadian Journal of Emergency Medicine, 2015
4. American College of Emergency Physicians, DART Guidelines, 2018
5. Mayr FB, et al. JAMA, 2017
6. Tabak YP, et al. Journal of Clinical Microbiology, 2008
7. Nguyen MH, et al. Annals of Internal Medicine 2019
8. Voigt, C, et al. Manuscript under review, 2019