Infectious Diseases

Improved patient care with accurate, targeted therapy days faster

The early detection and identification of clinically important organisms, including the most prevalent ESKAPE pathogens,1 enables clinicians to provide earlier targeted therapy for their patients.

Limitations of blood culture

Until now, the only way to provide species-specific diagnostic results was with a blood culture. Blood culture is severely limited by poor sensitivity, requiring multiple blood culture sets, and false negative test results, often resulting from interference from antimicrobial drugs in the bloodstream.2,3 False negative test results have led to an overreliance on empiric therapy and the protocol of running 3 to 4 blood cultures per patient, which further delays the time to test result.

Rapid diagnostics without the wait for blood culture

The FDA-cleared and CE-marked T2Bacteria® and T2Candida® Panels provide clinicians with new tools for accurate species-specific diagnostic results in 3 to 5 hours directly from a 4 mL whole blood sample – without the wait for blood culture. These panels detect the most serious bacterial and fungal pathogens often not susceptible to first-line empiric therapy.

Faster time to species identification in hospitals

  • Recent data from ECCMID by Dr. De Angelis and colleagues demonstrated that E. faecium was detected in 4 hours vs. 28 hours using traditional blood culture-based technology.
  • In a Case Study by Dr. De Angelis and colleagues presented at ECCMID, a rapid T2 result picked up a polymicrobial infection in 4 hours vs. 41 hours by traditional blood culture-based method, concluding that “the T2Bacteria Panel detects infections and poly-microbial infections faster than blood culture”.
  • A study from Henry Ford Health System demonstrated that patients tested with the T2Candida Panel were treated in a median of 5 hours compared to a median of 44 hours for blood culture, representing an eightfold improvement in time to delivery of appropriate therapy.4
  • A study from Lee Health demonstrated the meantime to appropriate therapy from the first positive blood culture was 34 hours. In contrast, the time from blood draw to initiation of appropriate antifungal therapy for T2Candida-positive patients was only 6 hours.5
  • In the T2Bacteria pivotal clinical trial conducted in 11 U.S. centers with 1,427 patients, investigators demonstrated positive results 2.5 days faster for panel targets, with highly accurate results and – unlike blood culture – no detection of antimicrobial interference.6

Demonstrated improvement in patient care

A growing body of data is demonstrating the positive impact of rapid diagnostics and the improvement inpatient care. Infectious disease experts from the University of Pittsburgh published a peer-reviewed study that shows how to effectively incorporate T2Candida into clinical pathways.7

In the study, T2 Magnetic Resonance Assay Improves Timely Management of Candidemia, by Wilson and colleagues published in the Journal of Antimicrobial Stewardship demonstrate a reduction in time to species ID (p<0.001), a reduction in median time to appropriate antifungal therapy (p<0.003) as well as an increase in detection of ocular candidiasis cases (p<0.028).4

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1. Karlowsky J. et al. Annals of Clinical Microbiology and Antimicrobials, 2004
2. Clancy CJ, Nguyen MH. Clinical Infectious Diseases, 2013
3. Cockerill III FR, et al. Clinical Infectious Diseases, 2014
4. Wilson NM, et al. Journal of Antimicrobial Stewardship, 2017
5. Patch ME, et al. Journal of Antimicrobial Chemotherapy, 2018
6. Nguyen MH, et al. Annals of Internal Medicine 2019.
7. Clancy CJ and Nguyen MH. Diagnostic Microbiology and Infectious Disease, 2018
8. Mylonakis E, et al. Clinical Infectious Diseases, 2015
* A combination of samples was run in both the prospective and contrived arms of the study. T2Bacteria showed an overall average sensitivity of 90% in the prospective arm of the study, with an overall average PPA of 97% in the contrived arm of the study.