Utilizing a Negative T2Bacteria Result

81 year old female admitted with a one-day history of fever, rigors, weakness, and confusion. Blood and urine cultures were ordered as well as IV antibiotics.

Discussion/Decision Making Based on T2Bacteria Result

At this point in time, the hospital has not adopted T2Bacteria, however, another hospital in their system has. Given the high likelihood that the repeat BCx would be negative, they were asked to draw a blood sample on the day the patient was ready for discharge and send it to the institution that currently utilized the T2Bacteria Panel.

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Candida parapsilosis bloodstream infection¹

The T2Candida Panel was used to assess for the presence of disease and continuation of antifungal therapy, despite negative blood cultures.

Discussion

Rapid molecular diagnostics such as T2MR technology may help with prognosis of invasive candidiasis. For our case, the T2Candida Panel was utilized upon follow up to assess clearance of candidemia along with clinical symptoms.

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Urinary Tract Infection: Suspected Sepsis

83-year-old male presented to the emergency department with urinary retention.

Had the T2Bacteria test been performed and result been reported immediately after collection, the patient could have been initiated on effective empiric therapy over 24 hours sooner, and P. aeruginosa bacteremia identified over two days earlier.

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Community Acquired Pneumonia

Patient presented to the emergency department with shortness of breath, cough, fever and chills.

A rapid T2Bacteria result could have allowed for more informed treatment decisions, including the initiation of earlier effective therapy over 30 hours sooner.

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Suspected urinary tract infection

91-year-old female presented to the emergency department with several day history of fever, chills, and nausea/vomiting.

Had the T2Bacteria^® test been performed and result been reported immediately after collection, the patient could have potentially avoided premature discharge and readmission.

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Deep-seated invasive candidiasis in a liver recipient

Patient with insulin-dependent diabetes mellitus, primary sclerosing cholangitis, multiple bacteremic episodes and recent liver transplant was admitted.

In this case, T2Candida^® results could have permitted earlier focused therapy and aided with the diagnosis of invasive Candida infection and lead to appropriate antifungal therapy. Unfortunately, the T2Direct Diagnostics^™ results were not in clinical use at the time and not obtained until after patient death.

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Suspected aspiration pneumonia vs HCAP

Patient presents to the Emergency Department from nursing home with fever, dyspnea, and altered mental status.

Discussion

At the time of admission, this patient had blood cultures obtained, and T2Bacteria ordered. At Piedmont Columbus Regional, patient selection for T2Bacteria testing was based on >2 SIRS criteria PLUS suspected source of infection PLUS hypotension or altered mental status. This patient was positive for 2 of 4 SIRS criteria and had a suspected cause of infection and altered mental state, thus meeting criteria for testing.

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Suspected Intra-abdominal sepsis

Patient presents with suspected sepsis

Discussion

Upon admission, the patient was initially given the broad spectrum antibiotics linezolid, aztreonam, and metronidazole for the treatment of suspected intra-abdominal sepsis. Due to the patient’s recent healthcare exposure, she was at risk for organisms such as MRSA (methicillin-resistant Staphylococcus aureus) and Pseudomonas aeruginosa in addition to the more common causes of intra-abdominal infection such as enterobacteriaceae and anaerobic organisms.

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Utilizing a Negative T2Bacteria Result

81 year old female admitted with a one-day history of fever, rigors, weakness, and confusion. Blood and urine cultures were ordered as well as IV antibiotics.

Discussion/Decision Making Based on T2Bacteria Result

Candida parapsilosis bloodstream infection¹

The T2Candida Panel was used to assess for the presence of disease and continuation of antifungal therapy, despite negative blood cultures.

Discussion

Urinary Tract Infection: Suspected Sepsis

83-year-old male presented to the emergency department with urinary retention.

Community Acquired Pneumonia

Patient presented to the emergency department with shortness of breath, cough, fever and chills.

Suspected urinary tract infection

91-year-old female presented to the emergency department with several day history of fever, chills, and nausea/vomiting.

Deep-seated invasive candidiasis in a liver recipient

Patient with insulin-dependent diabetes mellitus, primary sclerosing cholangitis, multiple bacteremic episodes and recent liver transplant was admitted.

Suspected aspiration pneumonia vs HCAP

Patient presents to the Emergency Department from nursing home with fever, dyspnea, and altered mental status.

Discussion

Suspected Intra-abdominal sepsis

Patient presents with suspected sepsis

Discussion

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