T2MR Technology

T2 Magnetic Resonance (T2MR®) – Our technology platform for next generation diagnostics

T2MR is a diagnostic detection method – utilizing miniaturized magnetic resonance technology that measures how water molecules react in the presence of magnetic fields. The T2MR technology platform offers a fast, simple and sensitive alternative to existing diagnostic methodologies.  

T2MR technology powers all of the diagnostic innovation at T2 Biosystems and enables the detection of a variety of different targets including:

  • Molecular targets – e.g., DNA, pathogen cells
  • Immunodiagnostics – e.g., proteins
  • A broad range of hemostasis measurements

T2MR and nanotechnology

For molecular and immunodiagnostics targets, T2MR utilizes advances in the field of nanotechnology by deploying particles with superparamagnetic properties that enhance the magnetic resonance signals of specific binding events. When particles coated with target-specific binding agents are added to a sample containing the target, the particles bind to and cluster around the target. This clustering changes the microscopic environment of water molecules in that sample, which in turn alters the magnetic resonance signal, or the T2 relaxation signal that we measure, indicating the presence, absence or concentration of the target.

Direct detection from sample

Unlike all other detection methods, T2MR is the first detection technology that can quickly and accurately identify molecular targets within patient samples without the need for purification or extraction of target molecules from the sample. T2MR technology can eliminate these time- and labor-intensive steps because the T2 relaxation signal is not compromised or disrupted by the sample background, even for the highly complex sample background that is present in blood from patients suspected of sepsis.

This differs entirely from diagnostic systems that rely on traditional polymerase chain reaction (PCR) where purification and extraction are required – which can cause 90% of the target to be lost.1 Due to these sensitivity limitations, these systems require a time consuming and often insensitive blood culture to allow them to detect at the low levels required for the pathogens associated with sepsis.

Low limits of detection and high sensitivity

T2MR technology enables the T2Dx Instrument and T2Candida Panel’s low limit of detection, as low as 1 CFU/mL, compared to the 100 to 1,000 CFU/mL required by PCR-based in vitro diagnostics. Additionally in a peer-reviewed publication, the T2Candida Panel demonstrated 99.4% specificity and 91.1% sensitivity.2 T2MR performs equally as well in the presence of anti-microbial therapy which has been shown to inhibit blood culture.

T2MR in hemostasis

For hemostasis measurements, particles are not required because T2MR is highly sensitive to changes in the microenvironment of a blood sample, such as clot formation, contraction and lysis, which alter the T2 relaxation signal. This enables the rapid identification of clinically relevant hemostasis changes. 

T2MR in other applications

Over 200 studies published in peer-reviewed journals have featured T2MR in a breadth of applications including the direct detection and measurement of targets such as whole blood, plasma, serum, saliva, sputum and urine.  

We believe the potential applications for T2MR extend within and outside of the in vitro diagnostics market, including environmental, food safety, industrial and veterinary applications.

The T2Dx Instrument and T2Candida Panel have received marketing authorization from the U.S. Food and Drug Administration. All other T2 Biosystems products are considered investigational and for research use only.


1. PLoS ONE | www.plosone.org | October 2010 | Volume 5 | Issue 10 | e13387 
1. Mylonakis, E., Clancy, C.J., Ostrosky-Zeichner, et. al. (2015). T2 Magnetic Resonance Assay for the Rapid Diagnosis of Candidemia in Whole Blood: A Clinical TrialClinical infectious diseases, ciu959.