T2Bacteria Positive while Cultures Remained Negative

An elderly patient presented to the ED with nausea, myalgia, and insomnia

Discussion

This case highlights the benefit of the T2Bacteria Panel’s ability to provide species identification in the presence of antimicrobial therapy rapidly.  Using T2Bacteria enabled the identification of E.coli in a patient on inadequate therapy for a urinary tract infection (UTI).

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Rapid T2Bacteria Result Helps Prevent Potential Complications due to Premature Discharge

A patient was admitted with a two-day history of right lower quadrant pain, fever, and vomiting

Discussion

This case highlights the benefit of rapid species identification with the T2Bacteria Panel and the potential prevention of additional sequelae with a premature discharge from the ED.

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High Negative Predictive Value Enables De-escalation of Therapy

A 72 year-old-patient presented to the ER with productive cough for three days, left flank pain, and intermittent nausea

Discussion

This case highlights the benefits of using the high negative predictive value (NPV) of the T2Bacteria Panel for early de-escalation of therapy, mainly when using antimicrobial agents that can commonly cause acute kidney injury.

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De-escalation of Therapy Before Blood Culture Result is Returned

A severely dehydrated elderly patient was admitted for septic shock overnight

Discussion

This case highlights not only T2Bacteria’s ability to rapidly identify specific bacterial pathogens in whole blood but also the capability to detect the causative organism in the presence of antibiotics where blood cultures remained negative, as well as an opportunity to use the result to de-escalate therapy.

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Critical Results Received without Interference from Empiric Therapy

Patient presented to the emergency department 5 days after appendectomy

Discussion

This case highlights the benefit of the T2Bacteria Panel’s rapid bacterial species identification in a scenario where a patient has already received several days of empiric therapy without significant clinical improvement. Once the causative organism was identified and effective therapy was initiated, the patient experienced rapid clinical improvement. This improvement enabled the patient to be discharged 2 days after the T2Bacteria result, potentially resulting in a reduced length of stay.

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Rapid Targeting of Therapy Based on T2Bacteria

An 86 year old patient transferred to the treating hospital with signs of septic shock

Discussion

This case highlights the benefit of T2Bacteria’s rapid bacterial species identification, which allowed for a rapid escalation of antibiotic therapy and discontinuation of unnecessary antibiotics once Pseudomonas aeruginosa was identified.

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Escalation of Appropriate Therapy for P. Aeruginosa

86-year-old patient with a past medical history of ischemic stroke, anemia, diabetes, and hypertension was transferred to the Intensive Care Unit

Discussion

Therapy was escalated to appropriately cover the P. aeruginosa infection in a geographic region endemic for multi-drug resistant P. aeruginosa that was not identified via the blood culture. The patient recovered from the infection and was discharged to a rehabilitation facility.

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Early ID of S. aureus Endocarditis Using T2Bacteria

54-year-old male, with a past medical history of Hepatitis C, presented to the emergency department

Discussion

This case highlights the benefit of the T2Bacteria Panel’s rapid bacterial species identification. Using T2Bacteria allowed for early identification of S. aureus endocarditis in a patient with a limited medical history that had been transferred from an outside hospital. Based on the T2Bacteria results, unnecessary antibiotics were discontinued on Day 1, and the patient received cardiology and infectious disease consultations for the management of endocarditis. The patient’s follow-on blood cultures were negative, likely due to the presence of antibiotics, but the S. aureus bacteremia was confirmed from a blood culture draw obtained prior to admission.

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Earlier Targeted Therapy Based on T2 Positive

52-year-old male, currently undergoing hemodialysis three times weekly with a complicated medical history

Discussion

This case highlights the benefit of the T2Bacteria Panel’s rapid species identification, allowing for the rapid initiation of appropriate antimicrobial therapy and resulting in clinical improvement.

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Male nurses standing over a patient in a hospital bed

Septic Shock Secondary to Pyelonephritis

A 55-year-old male presented to the hospital from an outside facility with sepsis secondary to pyelonephritis.

Discussion

This case highlights not only T2Bacteria’s ability of rapid identification but also the capability to detect the causative organism in the presence of antibiotics. The patient, in this case, received a dose of ceftriaxone and azithromycin before the blood cultures and T2Bacteria were drawn. Bloodstream infection was missed by blood culture but was identified with rapid detection provided by the T2Bacteria Panel. The use of T2Bacteria, in this case, allowed an early confirmation of effective antibiotic therapy.

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  • According to the CDC, of the 154 million prescriptions for antibiotics written in doctors' offices and emergency departments each year, 30% are unnecessary.12