Male nurses standing over a patient in a hospital bed

T2Bacteria Identifies Causative Pathogen in a Critically Ill Patient with a Respiratory Infection

A 20-year-old patient with a history of lupus presented to the emergency department with shortness of breath

Discussion

This case highlights the benefit of T2Bacteria’s rapid bacterial species identification, which enabled early identification of the causative pathogen in a critically-ill, immunocompromised patient. Bacterial infections commonly occur following successful treatment of viral infections.  These infections are often missed due to prior antimicrobial use, especially in at-risk patient populations, leading to treatment delays and negative clinical outcomes. 

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Utilizing T2Candida Result to Impact Appropriate Therapy

A 67-year-old patient had experienced infections, including multi-drug resistant pneumonia, sepsis, and C. difficile colitis during admission.

Discussion

This case highlights the benefit of T2Candida’s rapid fungal species identification, which allowed for the continuation of appropriate antifungal therapy as well as the discontinuation of unnecessary broad-spectrum antibiotics, resulting in clinical improvement.

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T2Bacteria Result Used to Alter Therapy

An elderly patient presented to the ED with a day-long history of fever, shaking, suprapubic pain, vomiting, and diarrhea

Discussion

This case highlights not only T2Bacteria’s ability of rapid identification but also the capability to detect the causative organism and use the result to de-escalate therapy.

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T2Bacteria Positive while Cultures Remained Negative

An elderly patient presented to the ED with nausea, myalgia, and insomnia

Discussion

This case highlights the benefit of the T2Bacteria Panel’s ability to provide species identification in the presence of antimicrobial therapy rapidly.  Using T2Bacteria enabled the identification of E.coli in a patient on inadequate therapy for a urinary tract infection (UTI).

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Rapid T2Bacteria Result Helps Prevent Potential Complications due to Premature Discharge

A patient was admitted with a two-day history of right lower quadrant pain, fever, and vomiting

Discussion

This case highlights the benefit of rapid species identification with the T2Bacteria Panel and the potential prevention of additional sequelae with a premature discharge from the ED.

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High Negative Predictive Value Enables De-escalation of Therapy

A 72 year-old-patient presented to the ER with productive cough for three days, left flank pain, and intermittent nausea

Discussion

This case highlights the benefits of using the high negative predictive value (NPV) of the T2Bacteria Panel for early de-escalation of therapy, mainly when using antimicrobial agents that can commonly cause acute kidney injury.

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De-escalation of Therapy Before Blood Culture Result is Returned

A severely dehydrated elderly patient was admitted for septic shock overnight

Discussion

This case highlights not only T2Bacteria’s ability to rapidly identify specific bacterial pathogens in whole blood but also the capability to detect the causative organism in the presence of antibiotics where blood cultures remained negative, as well as an opportunity to use the result to de-escalate therapy.

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Critical Results Received without Interference from Empiric Therapy

Patient presented to the emergency department 5 days after appendectomy

Discussion

This case highlights the benefit of the T2Bacteria Panel’s rapid bacterial species identification in a scenario where a patient has already received several days of empiric therapy without significant clinical improvement. Once the causative organism was identified and effective therapy was initiated, the patient experienced rapid clinical improvement. This improvement enabled the patient to be discharged 2 days after the T2Bacteria result, potentially resulting in a reduced length of stay.

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Rapid Targeting of Therapy Based on T2Bacteria

An 86 year old patient transferred to the treating hospital with signs of septic shock

Discussion

This case highlights the benefit of T2Bacteria’s rapid bacterial species identification, which allowed for a rapid escalation of antibiotic therapy and discontinuation of unnecessary antibiotics once Pseudomonas aeruginosa was identified.

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Escalation of Appropriate Therapy for P. Aeruginosa

86-year-old patient with a past medical history of ischemic stroke, anemia, diabetes, and hypertension was transferred to the Intensive Care Unit

Discussion

Therapy was escalated to appropriately cover the P. aeruginosa infection in a geographic region endemic for multi-drug resistant P. aeruginosa that was not identified via the blood culture. The patient recovered from the infection and was discharged to a rehabilitation facility.

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  • According to the CDC, of the 154 million prescriptions for antibiotics written in doctors' offices and emergency departments each year, 30% are unnecessary.12