T2Bacteria enabled the detection of polymicrobial infection and the detection of a subsequent Enterococcus faecium infection in a patient where cultures remained negative. Rapid species identification led to targeted therapy and eventual discharge.
Klinik Favoriten | Vienna, Austria
Age and Sex: 53-year-old male
History: The patient had no history of chronic diseases
Presentation: The patient was admitted to the hospital with COVID-19 and respiratory failure and was mechanically ventilated
Risk Factors: The patient had multiple risk factors for infection.
- Presence in ICU
- Broad spectrum antimicrobial therapy
- Mechanical ventilation
Evaluation and Treatment
The patient was admitted to the hospital eight days after the onset of symptoms and then admitted to the ICU with COVID-19 and respiratory failure. The patient was mechanically ventilated.
Weaning was complicated due to ventilator-associated pneumonia.
The T2Bacteria Panel was positive for Staphylococcus aureus and Escherichia coli, and targeted therapy was initiated before culture results were returned.
A bronchoalveolar lavage sample was also positive for Staphylococcus aureus and Escherichia coli.
10 days later, the patient developed septic shock from an unknown source. Several blood, bronchoalveolar, and urine cultures were taken, but no growth occurred.
Another T2Bacteria Panel was run and was positive for Enterococcus faecium, leading to targeted therapy. A transesophageal echocardiogram revealed endocarditis of the native aortic valve.
After 42 days in the ICU, the patient was discharged to a rehabilitation facility.
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