Publications and Presentations

Showing: All publications (122)

Years: 2020

Prospective, non-interventional, multi-centre clinical study of the T2Resistance system for detection resistance genes in bacterial bloodstream infections: an interim analysis

Abstract, ECCMID 2020 | Walsh, T., Mencacci, A., Paggi, R., et al.
Early diagnosis in sepsis: T2 bacteria magnetic resonance assay versus blood culture

Abstract, ECCMID 2020 | Saiz Elizabet, Pt., Moreno, J.E., Roblas, R.F., et al.
Examining discordance in blood culture and T2 positivity in the detection of candidaemia: modelling the odds of blood culture and T2 discordance as a function of candidaemia risk factors

Abstract, ECCMID 2020 | Vahia, A., Alangaden, G., Suleyman, G.
Evaluation of T2MR for the diagnosis of bloodstream infections in paediatric patients

Abstract, ECCMID 2020 | Lucignano, B., Mancinelli, L., Onori, M., et al.
T2Bacteria panel in diagnostics of sepsis: the first experience at the University Hospital Centre Zagreb

Abstract, ECCMID 2020 | Mareković, I., Bosnjak, Z., Pleško, S., Tripkovic, V.
Using T2Dx and rapid AST with blood culture pre-sampling for combined ID and AST before blood culture positivity

Abstract, ECCMID 2020 | Malmberg, C., Flinkfeldt, L., Yien, P., et al.
Evaluation of T2MR in a Greek university intensive care unit

Abstract, ECCMID 2020 | Douka, E., Papachatzakis, L., Vrettou, C., et al.
T2 magnetic resonance technology in the diagnosis of sepsis and clinical impact in patient management

Abstract, ECCMID 2020 | Paggi, R., De Socio, G., Belati, A., et al.

Years: 2019

The T2Bacteria Assay is a Sensitive and Rapid Detector of Bacteremia that can be Initiated in the Emergency Department and has Potential to Favorably Influence Subsequent Therapy

Clinical Laboratory in Emergency Medicine | Voigt, C, Silbert, S, Widen, R, et al.
Keynote Presentation: World Anti-Microbial Resistance Congress 2019

Keynote Presentation, WAMR 2019 | Lowery T
Optimizing the Clinical Utilization of T2 Rapid Candida Panel at a Large Community Hospital

Poster Presentation, IDWeek 2019 | Thottacherry E, Heard G, Steuber T, et al.
Evaluation of the clinical Impact of the T2MR for the Diagnosis of Blood Stream Infections

Poster Presentation, IDWeek 2019 | Seitz T, Baumgartner S, Wenisch C, et al.
Evaluation of the T2Candida Panel as an Antifungal Stewardship Tool in Transplant and Non-Transplant Patients at a Tertiary Care Center

Poster Presentation, IDWeek 2019 | Chaudhry Z, Vahia A, Kathuria P, et al.
Comparison of T2Candida Assay with Blood Culture, Candida Sepsis Score and Serum Beta-D-glucan in Diagnosis of Candidemia

Poster Presentation, IDWeek 2019 | Nizami S, Zacharioudakis I, Aguero-Rosenfeld M, et al.
30- Day Mortality Among Patients with Candidemia Diagnosed by T2Candida Assay Alone: Influence of Risk Factors and Candida Species

Poster Presentation, IDWeek 2019 | White C, McCarty T, Lee R, et al.
Detection of antibiotic resistance genes in clinical samples using T2 Magnetic Resonance (T2MR®)

Poster Presentation, IDWeek 2019 | Snyder J, Manning B, Shivers R, et al.
The T2Bacteria Panel is a rapid detector of bacteremia and has potential to guide therapy in patients with hematological malignancies and hematopoietic stem cell transplantation (HSCT): a pilot study of non-culture molecular diagnostics

Poster Presentation, ECCMID 2019 | Walsh T, Helfgott D, Besien K, et al.
Development of a Highly Sensitive Assay for the Detection of Carbapenem-resistance Genes from Whole Blood by T2 Magnetic Resonance (T2MR®)

Poster Presentation, ECCMID 2019 | Manning B, Snyder J, ShiversR, et al.
The T2Bacteria assay is a sensitive and rapid detector of bacteremia that can be initiated in the emergency department and has potential to favorably influence subsequent therapy

Poster Abstract, ECCMID 2019 | C Voigt, S Silbert, R Widen, et al.
Rapid, culture-independent detection of resistance genes direct from whole blood by (T2MR®)

Poster Abstract, ASM 2019 | Manning B, Snyder J, Shivers R, et al.
Rapid, Direct-from-Blood Diagnostics that Enable Changes in Clinical Decisions

Showcase Presentation, ASM Microbe 2019 | Tom Lowery
A Rapid, Direct-from-Blood Diagnostic to Address Infections from Multidrug Resistant Organisms (MDROs)

Presentation, Biodefense World Summit 2019 | Tom Lowery
Blood culture-independent rapid diagnostic technology for improvement of time to bacterial species ID and earlier targeted antibiotic therapy.

Poster Presentation, MAD-ID 2019 | Guzman O, Estrada S, Clark J, et al.
Clinical Performance of T2Bacteria® Panel on Whole Blood for Early Identification of Bloodstream Infections in a Tertiary Care Teaching Hospital

Poster Presentation, MAD-ID 2019 | Tabb D, McAllister M, and Henderson T.J.
Rapid Species Identification Using T2Direct Diagnostics™ with Stewardship Interventions

Symposium Presentation, MAD-ID 2019 | Debbie Goff, Ryan Shields, Emily Weisz, Sandy Estrada
Performance of the T2Bacteria Panel for Diagnosing Bloodstream Infections. A Diagnostic Accuracy Study

Annals of Internal Medicine | M. Hong Nguyen, C.J. Clancy, W. Pasculle, et al.
Evaluation of the T2 magnetic resonance molecular technology for the direct identification of pathogens from blood samples in pediatric patients with suspected sepsis

Poster Abstract, ECCMID 2019 | B. Lucignano, M.T. D'urbano, L. Mancinelli, et al.
Real-life diagnostic performance of T2Candida among ICU patients with risk factors for invasive candidiasis

Poster Abstract, ECCMID 2019 | MC Arendrup, J Anderson, M Holten, et al.
Development of a Highly Sensitive Assay for the Detection of Carbapenem-resistance Genes from Whole Blood by T2 Magnetic Resonance (T2MR®)

Poster Abstract, ECCMID 2019 | B Manning, J Snyder, R Shivers, et al.
The T2Bacteria Panel is a rapid detector of bacteremia and has potential to guide therapy in patients with hematological malignancies and hematopoietic stem cell transplantation (HSCT): a pilot study of non-culture molecular diagnostics

Poster Abstract, ECCMID 2019 | T Walsh, D Helfgott, K Van Besien, et al.
Rapid Diagnostics Direct from Whole Blood: A Solution for Fast and Appropriate Antimicrobial Therapy

Slide Presentation, ECCMID 2019 | M Bauer, N Clancy, G De Angelis, T Walsh

Years: 2018

T2MR contributes to the very early diagnosis of complicated candidaemia. A prospective study

Journal of Antimicrobial Chemotherapy | Patricia Munoz, Antonio Vena, Marina Machado, et al.
T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study

Journal of Antimicrobial Chemotherapy | Patricia Munoz, Antonio Vena, Marina Machado, et al.
Potential role of T2Candida in the management of empirical antifungal treatment in patients at high risk of candidaemia: a pilot single-centre study

Journal of Antimicrobial Chemotherapy | Maddalena Giannella, Michela Paolucci, Greta Roncarati, et al.
T2Bacteria magnetic resonance assay for the rapid detection of ESKAPEc pathogens directly in whole blood

Journal of Antimicrobial Chemotherapy | Giulia De Angelis, Brunella Posteraro, Elena De Carolis, et al.
Accuracy of T2MR in diagnosing candidemia in critically ill patients: a prospective observational study

Poster Abstract, ESICM 2018 | O. Pouly, A. Rouze, B. Voisin, et al.
T2Candida® to guide antifungal and length of treatment of candidemia in a pediatric multivisceral transplant recipient

Medical Mycology Case Reports | Falces-Romero, I, Cendejas-Bueno, E, Laplaza-González, M et al.
Implementation of the T2 Biosystems T2Bacteria Panel in a level-one trauma center, safety net hospital

Poster Presentation, IDWeek 2018 | Robinson, C, Jackson, R, Sauaia, A, et al.
Incorporating T2Candida testing into rational antifungal (AF) management: A successful pilot study of diagnostic stewardship directed toward specific intensive care unit patients at-risk for sepsis due to invasive candidiasis

Poster Presentation, IDWeek 2018 | Shields, R, Clancy, CJ, Marini, R, et al.
T2Candida (T2MR) versus Beta-D-Glucan for preemptive antifungals stewardship in the intensive care unit

Poster Presentation, IDWeek 2018 | Gill, C, Kenney, R, Hencken, L, et al.
Impact of T2Candida Panel on species specific antifungal de-escalation

Poster Presentation, IDWeek 2018 | Chaudhry, Z, Vahia, A, Askar, S, et al.
Novel T2Candida Panel assay compared to blood cultures for detection of candidemia in transplant and non-transplant patients

Poster Presentation, IDWeek 2018 | Hussain, N, Vahia, A, Chaudhry, Z, et al.
Diagnosing candidemia with the T2Candida Panel: An instructive case of septic shock in which blood cultures were negative

Diagnostic Microbiology and Infectious Disease | Clancy, CJ, & Nguyen, MH
T2Candida® to guide antifungal and length of treatment of candidemia in a pediatric multivisceral transplant recipient

Medical Mycology Case Reports | Falces-Romero, I, Cendejas-Bueno, E, Laplaza-González, M et al.
T2 Magnetic Resonance to monitor hemostasis. In seminars in thrombosis and hemostasis.

Thieme Medical Publishers | Cuker, A, Marturano, JE, Carinato, ME, et al.
PCR-based nethods for the diagnosis of invasive candidiasis: Are they ready for use in the clinic?

Future Microbiology | Nguyen, MH, & Clancy, CJ
The efficacy of T2 Magnetic Resonance assay in monitoring candidemia after the initiation of antifungal therapy: The serial therapeutic and antifungal monitoring protocol (STAMP) trial.

Journal of Clinical Microbiology | Mylonakis, E, Zacharioudakis, IM, Clancy, CJ
T2Bacteria Panel: A rapid, culture-independent assay for identification of sepsis causative agents

Poster Presentation, ASM Microbe 2018 | Roberts, KM, Lapp, HS, George E. Barringer, GE et al
Validation of a rapid diagnostic test on whole blood for early identification of pathogens in patients in the intensive care unit

Poster Presentation, ASM Microbe 2018 | Pickens, C, Qi, ., Malcynzski, M, et al.
Clinical performance of T2Bacteria among patients with bloodstream infections due to five common bacterial species

Poster Presentation, ASM Microbe 2018 | Nguyen, MH, Pasculle, W, Pappas, PG, et al.
Comparative clinical evaluation of the T2Bacteria Panel versus blood culture for the diagnosis of bacteremia

Oral Presentation, ECCMID 2018 | Nguyen, MH
Use of T2MR in invasive candidiasis with and without candidemia

Future Microbiology | Zacharioudakis, IM, Zervou, FN & Mylonakis, E
Evaluation of a new T2 Magnetic Resonance assay for rapid detection of emergent fungal pathogen Candida auris on clinical skin swab samples

Mycoses | Sexton, DJ, Bentz, ML, Welsh, RM, & Litvintseva, AP
T2 Magnetic Resonance assay: Overview of available data and clinical implications

Journal of Fungi | Zacharioudakis, IM, Zervou, FN, & Mylonakis, E
Beyond blood culture: Whole blood diagnostics and antimicrobial stewardship

Journal of antimicrobial chemotherapy, Volume 73, Issue suppl 4, 1 March 2018
Detecting infections rapidly and easily for candidemia trial, part 2 (DIRECT2): A prospective, multicenter study of the T2Candida Panel

Clinical Infectious Diseases | Clancy, CJ, Pappas, PG, Vazquez, J, et al.
Evaluation of the T2Bacteria Panel (T2BP) compared to standard blood culture at Ochsner Medical Center.

Poster Presentation, ASM Microbe 2018 | Ogawa, M, Wargo, C, Marty-Vigo, H, et al.

Years: 2017

T2 Magnetic Resonance assay improves timely management of candidemia

Journal of Antimicrobial Stewardship | Wilson, N, Alangaden, G, Tibbetts, R, et al.
Rapid evaluation of platelet function with T2 Magnetic Resonance

American Journal of Clinical Pathology | Cuker, A, Husseinzadeh, H, Lebedeva, T, et al.
T2 Magnetic Resonance-based direct detection of three Lyme disease-related Borrelia species in whole blood samples

Journal of Clinical Microbiology | Snyder, J, Giese, H, Bandoski-Gralinski, C, et al.

Years: 2016

Implementation of T2 Magnetic Resonance into the Antimicrobial Stewardship

Poster Presentation, ID Week 2016 | Kenney R, Dwivedi S, Kendall R, et al.
Performance evaluation of the T2Candida Panel in the ICU setting – Data from an ongoing study

Poster Presentation, ASM Microbe 2016 | Arendrup, MC, Schierbeck, J, Reiter, N, et.al.
Investigational study: Whole blood platelet activity measurements multiplexed with quantitative fibrinogen, clot time and fibrinolysis measurements by T2MR®

Poster Presentation, ISTH 2015 | Smith, R, Papkov, V, Andre, P, et al.
T2 Magnetic Resonance improves the timely management of candidemia

Poster Presentation, IDWeek 2016 | Wilson, NM, Kenney, RM, Tibbetts, RJ, et al.
Antifungal prescribing during initial implementation of candidemia early detection and species identification testing with T2Candida Panel

Poster Presentation, IDWeek 2016 | Patel, F, and Young, E
Intra-abdominal candidiasis: The importance of early source control and antifungal treatment

PLOS ONE | Vergidis, P, Clancy, CJ, Shields, RK, et al.
Evaluation of BacT/Alert FA blood culture bottles and T2Candida assay for detection of Candida in the presence of antifungals

Poster Presentation, ASM Microbe 2016 | Beyda, ND, Amadio, J, Rodriguez, JR, et al.
Performance evaluation of the T2Candida Panel in the ICU setting – Data from an ongoing study

Poster Presentation, ASM Microbe 2016 | Arendrup, MC, Schierbeck, J, Reiter, N, et.al.
T2Candida provides rapid and accurate species identification in pediatric cases of candidemia

American Journal of Clinical Pathology | Hamula, CL, Hughes, K, Fisher BT, et al.
T2MR® platelet analysis enables fast and accurate diagnosis of qualitative platelet disorders in microliter volumes of whole blood

Poster Presentation, THSNA 2016 | Husseinzadeh, H, Cuker, A, Lebedeva, T, et al.
New frontiers in in vitro medical diagnostics by low field T2 Magnetic Resonance relaxometry

Trends in Analytical Chemistry | Luo, ZX, Fox, L, Cummings, M, et al.
Novel T2 Magnetic Resonance assay compared to standard blood cultures for detection of candidemia

Poster Presentation, IDWeek 2016 | Dwivedi, S, Ordaya, E, Kezlarian, B, et al.

Years: 2015

Invasive Candidiasis

The New England Journal of Medicine | Bart Jan Kullberg, M.D., Ph.D., and Maiken C. Arendrup, M.D., Ph.D.
Invasive Candidiasis

New England Journal of Medicine | Kullberg, BJ, & Arendrup, MC
T2Bacteria: Rapid and sensitive detection and identification of sepsis pathogens in whole blood specimens by T2MR®

Poster Presentation, AMP 2015. | Neely, L, Plourde, D, Suchocki, A, et al.
T2Candida is more sensitive and rapid than blood culture for monitoring candidemia in patients with proven infection

Poster Presentation, ICAAC/ICC 2015 | Pappas, PG, Nguyen, MH, and Mylonakis, E.
T2MR and T2Candida: Novel technology for the rapid diagnosis of candidemia and invasive candidiasis

Future Microbiology | Pfaller, MA, Wolk, DM, and Lowery, TJ.
Investigational study: T2MR® platelet analysis correlates with LTA and reveals unique details of ADP-mediated platelet activation in whole blood

Poster Presentation, ISTH 2015 | Cuker, A, Lebedeva, T, Husseinzadeh, H, et al.
Investigational study: T2Candida provides rapid and accurate species identification in pediatric cases of candidemia

Poster Presentation, ASM Microbe 2015. | Hughes, KT, Zaoutis, T, Fisher, B, et al.
The economic impact of rapid Candida species identification by T2Candida among high-risk patients

Future Microbiology | Bilir, SP, Ferrufino, CP, Pfaller, MA, and Munakata, J
T2 Magnetic Resonance assay for the rapid diagnosis of candidemia in whole blood: A clinical trial

Clinical Infectious Diseases | Mylonakis, E, Clancy, CJ, Ostrosky-Zeichner, L, et al.
Nanotechnology

JAMA | Langer, R, and Weissleder, R

Years: 2014

Clot contraction: Compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin

Blood | Cines, DB, Lebedeva, T, Nagaswami, C, et al.
T2 Magnetic Resonance: A diagnostic platform for studying integrated hemostasis in whole blood—proof of concept

Clinical Chemistry | Skewis, LR, Lebedeva, T, Papkov, V, et al.
A (nother) test meant to fill the gap between in vivo and ex vivo hemostasis

Clinical Chemistry | Tripodi, A.
A new red cell shape helps the clot

Blood | Ariëns, RA
Invesitgational study: Intra-abdominal candidiasis: Description of an under-appreciated disease and a case report of rapid diagnosis by whole blood T2Candida assay

Poster Presentation, IDWeek 2014 | Clancy, CJ, Vergidis, P, Shields, RK, and Nguyen, MH

Years: 2013

Comparison of the T2Dx Instrument with T2Candida assay and automated blood culture in the detection of Candida species using seeded blood samples

Diagnostic Microbiology and Infectious Disease | Beyda, ND, Alam, MJ, & Garey, KW
Magnetic barcode assay for genetic detection of pathogens

Nature Communications | Liong, M, Hoang, AN, Chung, J, et al.
T2 Magnetic Resonance enables nanoparticle-mediated rapid detection of candidemia in whole blood

Science Translational Medicine | Neely, LA, Audeh, M, Phung, NA, et al.
Nuclear magnetic resonance nanotechnology: Applications in clinical diagnostics and monitoring

Encyclopedia of Analytical Chemistry | Skewis, LR, Demas, V, & Lowery, TJ
A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria

Nature Nanotechnology | Chung, HJ, Castro, CM, Im, H, et al.

Years: 2012

Fluorochrome‐functionalized magnetic nanoparticles for high‐sensitivity monitoring of the polymerase chain reaction by magnetic resonance

Angewandte Chemie International Edition | Alcantara, D, Guo, Y, Yuan, H, et al.
Pattern recognition of cancer cells using aptamer-conjugated magnetic nanoparticles

ACS Nano | Bamrungsap, S, Chen, T, Shukoor, MI, et al.

Years: 2011

Supramolecular host–guest interaction for labeling and detection of cellular biomarkers

Angewandte Chemie International Edition | Agasti, SS, Liong, M, Tassa, C, et al.
Micro-NMR for rapid molecular analysis of human tumor samples

Science Translational Medicine | Haun, JB, Castro, CM, Wang, R, et al.
Palm NMR and 1-chip NMR

IEEE Journal of Solid-State Circuits | Sun, N, Yoon, TJ, Lee, H, et al.
Magnetic resonance for in vitro medical diagnostics: Superparamagnetic nanoparticle-based magnetic relaxation switches

New Journal of Physics | Demas, V, & Lowery, TJ
Miniature magnetic resonance system for point of care diagnostics

Lab on a Chip | Issadore, D, Min, C, Liong, M, et al.
Implantable magnetic relaxation sensors measure cumulative exposure to cardiac biomarkers

Nature Biotechnology | Ling, Y, Pong, T, Vassiliou, CC, et al.

Years: 2010

Magnetic relaxation-based platform for multiplexed assays

Analyst | Ling, Y, Vassiliou, CC, & Cima, MJ
Detection of carbohydrate binding proteins using magnetic relaxation switches

Analytical Chemistry, | Kulkarni, AA, Weiss, AA, & Iyer, SS

Years: 2009

Implantable diagnostic device for cancer monitoring

Biosensors and Bioelectronics | Daniel, KD, Kim, GY, Vassiliou, CC, et al.
Nanoparticle−Target interactions parallel Antibody−Protein interactions

Analytical Chemistry | Koh, I, Hong, R, Weissleder, R, & Josephson, L
Ultrasensitive detection of bacteria using core–shell nanoparticles and an NMR‐filter system

Angewandte Chemie International Edition | Lee, H, Yoon, TJ, & Weissleder, R
Rapid detection and profiling of cancer cells in fine-needle aspirates

Proceedings of the National Academy of Sciences | Lee, H, Yoon, TJ, Figueiredo, JL, et al.
Nanomaterials‐based magnetic relaxation switch biosensors

Nanotechnologies for the Life Sciences | Lowery, T.

Years: 2008

Chip–NMR biosensor for detection and molecular analysis of cells

Nature Medicine | Lee, H, Sun, E, Ham, D, & Weissleder, R
Preparation of iron oxide-based calcium sensors for MRI

Nature Protocols | Atanasijevic, T, & Jasanoff, A
Sensitive NMR sensors detect antibodies to influenza

Angewandte Chemie | Koh, I, Hong, R, Weissleder, R, & Josephson, L

Years: 2007

Magnetic relaxation switch detection of human chorionic gonadotrophin

Bioconjugate Chemistry | Kim, GY, Josephson, L, Langer, R, & Cima, MJ
Multi-reservoir device for detecting a soluble cancer biomarker

Lab on a Chip | Daniel, KD, Kim, GY, Vassiliou, CC, et al.

Years: 2006

Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin

Proceedings of the National Academy of Sciences | Atanasijevic, T, Shusteff, M, Fam, P, & Jasanoff, A
Continuous analyte sensing with magnetic nanoswitches

Small | Sun, EY, Weissleder, R, & Josephson, L
Dynamic imaging with MRI contrast agents: quantitative considerations

Magnetic Resonance Imaging | Shapiro, MG, Atanasijevic, T, Faas, H, et al.

Years: 2004

Novel nanosensors for rapid analysis of telomerase activity

Cancer Research | Grimm, J, Perez, JM, Josephson, L, & Weissleder, R
Magnetic relaxation switch immunosensors detect enantiomeric impurities

Angewandte Chemie International Edition | Tsourkas, A, Hofstetter, O, Hofstetter, H, et al.

Years: 2003

Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media

Journal of the American Chemical Society | Perez, JM, Simeone, FJ, Saeki, Y, et al.
Magnetic sensors for protease assays

Angewandte Chemie International Edition | Zhao, M, Josephson, L, Tang, Y, & Weissleder, R

Years: 2002

Magnetic relaxation switches capable of sensing molecular interactions

Nature Biotechnology | Perez, JM, Josephson, L, O'Loughlin, T, et al.
DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents

Journal of the American Chemical Society | Perez, JM, O'Loughin, T, Simeone, FJ, et al.

Years: 2001

Magnetic nanosensors for the detection of oligonucleotide sequences

Angewandte Chemie | Josephson, L, Perez, JM, & Weissleder, R