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Sepsis in the ICU

Achieve faster time to targeted therapy — Species identification within 3 to 5 hours of first blood draw

Sepsis is one of the top five diagnoses for adult admissions in the ICU1

During an individual stay in the Intensive Care Unit (ICU), sepsis is identified in 29.5% of patients,² with high mortality rates for those with bloodstream infections (BSIs) that range from 26% to 47%.³

Blood cultures are routinely ordered for sepsis patients in the ICU, but they have certain limitations, including inconsistent results due to slow growth⁴, interference from previously administered antimicrobials, and difficulty with identifying polymicrobial infections.⁵

Culture-Independent Diagnostics for Sepsis

T2 Biosystems Sepsis Panels 

T2 Biosystems has developed the first and only diagnostic test panels to provide species identification directly from a whole blood sample without waiting for a positive blood culture. The T2Bacteria® and T2Candida® Panels are run on the fully automated T2Dx® Instrument and are powered by T2 Magnetic Resonance (T2MR®) Technology. 

With results in as little as 3 to 5 hours, physicians can target therapy before the second dose of empiric therapy has been administered. When every hour counts, T2Bacteria and T2Candida can provide rapid species identification for bacterial and fungal infections before the blood culture turns positive, enabling timely and targeted treatment for better patient outcomes. 

ICU Hospital Use Cases

PRESIDIO HOSPITAL | Caltanissetta, Italy
A T2Bacteria result facilitated the diagnosis of infective endocarditis that led to rapid initiation of targeted antibiotic therapy in a critically ill patient with prosthetic valve endocarditis. Fast species ID enabled targeted treatment 8 days before blood culture results were available.
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  1. Barrett, ML, et al. Agency for Healthcare Research and Quality. 2014.
  2. Sakr, Y, et al. Open Forum Infect Dis. 2018
  3. Wisplinghoff, H, et al. Clin Infect Dis. 2004
  4. Bourbeau, PP, et al. J Clin Microbiol. 2005
  5. Doualeh, et al. Int J Mol Sci. 2022
  6. Giannella, M, et al. Expert Rev. of Med. Dev. 2021
  7. Nguyen, M. H., et al. Annals of Internal Medicine. 2019 
  8. Clancy, N., et al. Clin Infect. Dis. 2018
  9. T2Bacteria Instructions for Use
  10. T2Candida Instructions for Use
  11. Mylonakis, E., et al. Clinical Infectious Diseases. 2015