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Case study highlighting the rapid identification of Candida infection while cultures remained negative

Gulf Coast Medical Center, Lee Health | Fort Meyers, FL

 

Presentation

A 75-year-old female presenting with abdominal pain and hypotension.

Patient History

Hypertension, hyperlipidemia, type 2 Diabetes mellites, ovarian cancer with metastases, placement of a percutaneous endoscopic gastrostomy (PEG) tube, and total parental nutrition (TPN) dependent. 

The patient was recently discharged after a prolonged hospital stay (3 weeks) and underwent several GI surgeries, most recently a bowel resection for duodenal perforation as a result of tumor erosion.

Surgical oncology, Gastroenterology, and Infectious Diseases services were all consulted to manage the case.

Evaluation and Treatment Decision

The identification of Candida glabrata/krusei with the T2Candida Panel prevented the inappropriate de-escalation of antifungal therapy in a high-risk patient.

Learn More

To learn more about T2Candida and this case study, watch the webinar, Real World Experience with T2Candida at a Community Health System

1. Chandler, E. Real World Experience with T2Candida at a Community Health System (Webinar). 2024

In both of these clinical case studies, T2Bacteria® identified the causative pathogen days sooner than blood culture and allowed for the earlier initiation of targeted therapy.1

Butler Health System | Butler, PA

Case 1
Age and Sex: 70-year-old male

Presentation: The patient presented with shortness of breath, hypothermia, hypertension and was admitted. The patient had no sepsis indicators and no action was taken for sepsis screening.

Vitals: T = 99.8; BP = 152/86; P = 70

Evaluation and Treatment

Day 0

• WBC = 23.2, MDW* = 23.05 lactic acid = 1.0,PCT = .32

• T2Bacteria Result: The T2Bacteria Panel was positive for Enterococcus faecium, and the patient was initiated on targeted therapy

Day 1

• Blood culture confirmed Enterococcus faecium.

T2Bacteria allowed for targeted therapy 20 hours faster than blood culture alone.

Case 2
Age and Sex: 67-year-old male

Presentation: The patient presented with altered mental status and hypotension, and was admitted. The patient had no sepsis indicators and no action was taken for sepsis screening.

Vitals: T not taken, BP= 62/44, P = 53

Evaluation and Treatment

Day 0

• WBC = 24.7, MDW* = 23.98, lactic acid = 1.0, PCT = 4.25

Day 1

T2Bacteria Result: The T2Bacteria Panel was positive for Pseudomonas aeruginosa, and the patient was initiated on targeted therapy

Day 3

• Blood culture confirmed Pseudomonas aeruginosa.

T2Bacteria allowed for targeted therapy 37 hours faster than blood culture alone.

Download Case Studies

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*This institution uses an algorithm combining Monocyte Distribution Width (MDW) from Beckman Coulter and white blood count (WBC) metrics as an indicator to run T2Bacteria.

  1. Patterson, R., Katsaros, S., Industry Showcase, ASM 2023
According to the CDC, of the 154 million prescriptions for antibiotics written in doctors’ offices and emergency departments each year, 30% are unnecessary.12

PUBLICATIONS

Over 200 studies published in peer-reviewed journals have featured T2MR in a breadth of applications.